Alexander Fetindsev

Alexander Fedintsev together with Alexey Moskalev, recently published an expansive review paper in which they propose a new hallmark of aging (Fedintsev, A., & Moskalev, A. (2020). Stochastic non-enzymatic modification of long-lived macromolecules-a missing hallmark of aging. Ageing Research Reviews, 101097).

The authors draw our attention to a phenomenon that is sometimes overlooked in the context of aging: the accumulation of damage to long-lived molecules caused by the non-enzymatic chemical reactions of glycation, carbonylation, and carbamylation. With time, these modifications inflict extensive damage to our bodies. The authors go as far as to cautiously suggest that this phenomenon might be the upstream cause of several known hallmarks of aging, such as cellular senescence.